No, because it’s 6:30am bro

Because nominal wealth relative to natural capital is true wealth /s. Fuck the world!!

Maybe, but if PGE2 signaling is disrupted in non-cartilage tissues, it could promote abnormal growth or inflammation. For example, PGE2 has complex roles in cancer and fibrosis. And if the drug isn’t perfectly specific, it might inhibit other enzymes or pathways. This is because 15-PGDH is active in other tissues (e.g., liver, muscle, bone). Inhibiting it systemically might affect these tissues, though the study suggests localized joint injection could minimize this I suppose…

Yeah but while PGE2 promotes cartilage repair, it also plays roles in inflammation, fever, and gastrointestinal issues. If PGE2 levels rise too high or in the wrong context, it could cause unwanted inflammation or side effects similar to NSAIDs (e.g. stomach irritation).

I can relate to what you’re saying. Also AMAB, but I think it relates to something psychosexual. Carl Jung believed that Eastern philosophical practices and Taoist exercise could bring about some form of enlightenment and ecstasy of life. It’s not too far off from the psychedelic movement in the West these days… Anyway, a week or two ago, my wife was rimming me, and I realised I needed to combine both my anal and penile selves (think Freud) together to enjoy that moment. It’s not easy but when you relax into it and balance your own yin/yang complete self, you can enjoy it… But if you don’t, it’ll feel like two different people in the same body. Hope that makes sense?